PittsburghV1, France, Analysis, bibRecord, 000067

Characterization of prophages containing "evolved" Dit/Tal modules in the genome of Lactobacillus casei BL23.

Identifieur interne : 000067 ( France/Analysis ); précédent : 000066; suivant : 000068

Characterization of prophages containing "evolved" Dit/Tal modules in the genome of Lactobacillus casei BL23.

Auteurs : María Eugenia Dieterle [Argentine] ; Joaquina Fina Martin [Argentine] ; Rosario Durán [Uruguay] ; Sergio I. Nemirovsky [Argentine] ; Carmen Sanchez Rivas [Argentine] ; Charles Bowman [États-Unis] ; Daniel Russell [États-Unis] ; Graham F. Hatfull [États-Unis] ; Christian Cambillau [France] ; Mariana Piuri [Argentine]

Source :

Applied Microbiology and Biotechnology [ 0175-7598 ] ; 2016-07-23.

RBID : Hal:pasteur-01498340

English descriptors

mix :
- Bacteriophage, Baseplate, Lactobacillus casei, Prophage.

Abstract

Lactic acid bacteria (LAB) have many applications in food and industrial fermentations. Prophage induction and generation of new virulent phages is a risk for the dairy industry. We identified three complete prophages (PLE1, PLE2, and PLE3) in the genome of the well-studied probiotic strain Lactobacillus casei BL23. All of them have mosaic architectures with homologous sequences to Streptococcus, Lactococcus, Lactobacillus, and Listeria phages or strains. Using a combination of quantitative real-time PCR, genomics, and proteomics, we showed that PLE2 and PLE3 can be induced-but with different kinetics-in the presence of mitomycin C, although PLE1 remains as a prophage. A structural analysis of the distal tail (Dit) and tail associated lysin (Tal) baseplate proteins of these prophages and other L. casei/paracasei phages and prophages provides evidence that carbohydrate-binding modules (CBM) located within these "evolved" proteins may replace receptor binding proteins (RBPs) present in other well-studied LAB phages. The detailed study of prophage induction in this prototype strain in combination with characterization of the proteins involved in host recognition will facilitate the design of new strategies for avoiding phage propagation in the dairy industry.

Url:

https://hal-riip.archives-ouvertes.fr/pasteur-01498340

DOI: 10.1007/s00253-016-7727-x

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000125
to stream Hal, to step Curation: 000125
to stream Hal, to step Checkpoint: 000072
to stream Main, to step Merge: 000073
to stream Main, to step Curation: 000073
to stream Main, to step Exploration: 000073
to stream France, to step Extraction: 000067

Links to Exploration step

Hal:pasteur-01498340

Le document en format XML

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<country>Argentine</country>
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</author>
<author><name sortKey="Bowman, Charles" sort="Bowman, Charles" uniqKey="Bowman C" first="Charles" last="Bowman">Charles Bowman</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-214819" status="INCOMING"><orgName>Pittsburgh Bacteriophage Institute</orgName>
<desc><address><addrLine>Department of Biological Sciences,Pittsburgh, PA 15260</addrLine>
<country key="US"></country>
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          <desc>            <address>              <country key="FR"></country>
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</hal:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Russell, Daniel" sort="Russell, Daniel" uniqKey="Russell D" first="Daniel" last="Russell">Daniel Russell</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-214819" status="INCOMING"><orgName>Pittsburgh Bacteriophage Institute</orgName>
<desc><address><addrLine>Department of Biological Sciences,Pittsburgh, PA 15260</addrLine>
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</tutelles>
</hal:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Hatfull, Graham F" sort="Hatfull, Graham F" uniqKey="Hatfull G" first="Graham F" last="Hatfull">Graham F. Hatfull</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-214819" status="INCOMING"><orgName>Pittsburgh Bacteriophage Institute</orgName>
<desc><address><addrLine>Department of Biological Sciences,Pittsburgh, PA 15260</addrLine>
<country key="US"></country>
</address>
</desc>
<listRelation><relation active="#struct-378064" type="direct"></relation>
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<tutelles><tutelle active="#struct-378064" type="direct"><org type="institution" xml:id="struct-378064" status="INCOMING">          <orgName>University of Pittsburgh</orgName>
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</tutelles>
</hal:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Cambillau, Christian" sort="Cambillau, Christian" uniqKey="Cambillau C" first="Christian" last="Cambillau">Christian Cambillau</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-199349" status="VALID"><idno type="RNSR">201220260Z</idno>
<idno type="IdRef">149981651</idno>
<orgName>Architecture et fonction des macromolécules biologiques</orgName>
<orgName type="acronym">AFMB</orgName>
<date type="start">2012</date>
<desc><address><addrLine>Faculté des Sciences de Luminy - Case 932 163, Avenue de Luminy13288 Marseille Cedex 09</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.afmb.univ-mrs.fr/</ref>
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          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
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          <date type="start">1939-10-19</date>
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<tutelle name="UMR7257" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID">          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>            <address>              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
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            </address>
            <ref type="url">http://www.inra.fr</ref>
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</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Piuri, Mariana" sort="Piuri, Mariana" uniqKey="Piuri M" first="Mariana" last="Piuri">Mariana Piuri</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-458638" status="INCOMING"><orgName>Departamento de Química Biológica</orgName>
<orgName type="acronym">IQUIBICEN-CONICE</orgName>
<desc><address><addrLine>Facultad de Ciencias Exactas y Naturales - Intendente Guiraldes 2160, C1428EGA Buenos Aire</addrLine>
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</address>
</desc>
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<desc><address><addrLine>Viamonte 430/44 C1053ABJ,  Ciudad de Buenos Aires</addrLine>
<country key="AR"></country>
</address>
<ref type="url">http://www.uba.ar/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Argentine</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1007/s00253-016-7727-x</idno>
<series><title level="j">Applied Microbiology and Biotechnology</title>
<idno type="ISSN">0175-7598</idno>
<imprint><date type="datePub">2016-07-23</date>
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</series>
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<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Bacteriophage</term>
<term>Baseplate</term>
<term>Lactobacillus casei</term>
<term>Prophage</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Lactic acid bacteria (LAB) have many applications in food and industrial fermentations. Prophage induction and generation of new virulent phages is a risk for the dairy industry. We identified three complete prophages (PLE1, PLE2, and PLE3) in the genome of the well-studied probiotic strain Lactobacillus casei BL23. All of them have mosaic architectures with homologous sequences to Streptococcus, Lactococcus, Lactobacillus, and Listeria phages or strains. Using a combination of quantitative real-time PCR, genomics, and proteomics, we showed that PLE2 and PLE3 can be induced-but with different kinetics-in the presence of mitomycin C, although PLE1 remains as a prophage. A structural analysis of the distal tail (Dit) and tail associated lysin (Tal) baseplate proteins of these prophages and other L. casei/paracasei phages and prophages provides evidence that carbohydrate-binding modules (CBM) located within these "evolved" proteins may replace receptor binding proteins (RBPs) present in other well-studied LAB phages. The detailed study of prophage induction in this prototype strain in combination with characterization of the proteins involved in host recognition will facilitate the design of new strategies for avoiding phage propagation in the dairy industry.</div>
</front>
</TEI>
<affiliations><list><country><li>Argentine</li>
<li>France</li>
<li>Uruguay</li>
<li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
<li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Marseille</li>
<li>Pittsburgh</li>
</settlement>
<orgName><li>Université d'Aix-Marseille</li>
<li>Université de Pittsburgh</li>
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</list>
<tree><country name="Argentine"><noRegion><name sortKey="Dieterle, Maria Eugenia" sort="Dieterle, Maria Eugenia" uniqKey="Dieterle M" first="María Eugenia" last="Dieterle">María Eugenia Dieterle</name>
</noRegion>
<name sortKey="Fina Martin, Joaquina" sort="Fina Martin, Joaquina" uniqKey="Fina Martin J" first="Joaquina" last="Fina Martin">Joaquina Fina Martin</name>
<name sortKey="Nemirovsky, Sergio I" sort="Nemirovsky, Sergio I" uniqKey="Nemirovsky S" first="Sergio I" last="Nemirovsky">Sergio I. Nemirovsky</name>
<name sortKey="Piuri, Mariana" sort="Piuri, Mariana" uniqKey="Piuri M" first="Mariana" last="Piuri">Mariana Piuri</name>
<name sortKey="Sanchez Rivas, Carmen" sort="Sanchez Rivas, Carmen" uniqKey="Sanchez Rivas C" first="Carmen" last="Sanchez Rivas">Carmen Sanchez Rivas</name>
</country>
<country name="Uruguay"><noRegion><name sortKey="Duran, Rosario" sort="Duran, Rosario" uniqKey="Duran R" first="Rosario" last="Durán">Rosario Durán</name>
</noRegion>
</country>
<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Bowman, Charles" sort="Bowman, Charles" uniqKey="Bowman C" first="Charles" last="Bowman">Charles Bowman</name>
</region>
<name sortKey="Hatfull, Graham F" sort="Hatfull, Graham F" uniqKey="Hatfull G" first="Graham F" last="Hatfull">Graham F. Hatfull</name>
<name sortKey="Russell, Daniel" sort="Russell, Daniel" uniqKey="Russell D" first="Daniel" last="Russell">Daniel Russell</name>
</country>
<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Cambillau, Christian" sort="Cambillau, Christian" uniqKey="Cambillau C" first="Christian" last="Cambillau">Christian Cambillau</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Characterization of prophages containing "evolved" Dit/Tal modules in the genome of Lactobacillus casei BL23.

Characterization of prophages containing "evolved" Dit/Tal modules in the genome of Lactobacillus casei BL23.

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